CONSULTANCY OFFERED BY NIRMALA COLLEGE OF PHARMACY

The Research & Development Cell is advancing its research facilities to extend our service to industries  and other research organizations in the areas:

Cyto-toxicity screening:

• MTT assay
• Apoptotic assay
• Antimitotic activity
• Antiangiogenic activity
• Cell proliferation assay
• RNA isolation and reverse transcription
• Gene expression analysis (RT-PCR)

Anticancer studies (Invitro and invivo):

• Invivo induction of cell line tumors.
• Evaluation of tumors.

Animal studies [Pharmacological screening models]:

• Anti-fertility.
• Anti-inflammatory.
• Antidiabetic.
• Models for neuroprotective and neurodegenerative disorders.
• Laboratory examination and estimation of blood using Autoanalyzer (animals and human).
• Anti- analgesic.
• Anti- convulsion.
• Muscle relaxant.
• Psychological tastings.
• Anti-microbial assay.
• Anti-Ulcer
• Wound healing activities
• Ant- Burn models
• Acute & Chronic Toxicity Studies.
• Hepatotoxicity
• Nephrotoxicity
• Heart/thoracic aorta and CNS toxicity
• Reproductive and Developmental toxicities in rat/mice pups
• Anti-anxiety and Anti-depressant.
• Antidiuretics.
• Anti-malarial.
• Chemical bioassays.
• Anti-mutagenic. (chromosomal abrasion)
• Preclinical studies on various pharmacological animal models with data collection, integration and validation.
• Biochemical tests
• Invitro-tissue experiments
• Psychopharmacological studies.
• Biological Data Analysis.

Docking studies [by using softwares]

• Chemsketch
• PASS prediction
• ADMET
• Molecular docking with PyRx

PHARMACEUTICAL CHEMISTRY AND ANALYTICAL RESERACH

• Phytochemical Screening and separation of phytochemicals by Column Chromatography.
• Estimation of Phytochemicals.
• Synthesis and identification of bioactive molecules.
• Insilico docking studies on target proteins.
• Drug design.
• Analytical method development and validation of Pharmaceuticals by UV spectrophotometer and HPLC.
• Characterization of organic molecules by IR Spectrophotometry.
• Sample Analysis by FTIR.

PHARMACEUTICAL PREPERATIONS, FORMULATION DEVELOPMENT & EVALUATIONS

• Development of tablets:
  • Immediate release tablets.
  • Sustained and controlled release tablets.
  • Delayed release tablets.
• Quality control test for granules and powders.
• Preparation of Hard Gelatin capsules.
• Development of coated tablets.
• Development of pellets.
• Development of semisolids and cosmetic preparations.
• All Quality control test for capsules and tablets.
• Microbial Assays.
• Antibiotic sensitivity studies.
• Leak test for ampoules, vials and other primary packing materials.
• Development and evaluation of liquid dosage forms-syrup, suspensions and emulsions.
• Accelerated stability studies for pharmaceutical dosage forms.
• Drug -Excipients  compatibility studies.
• Phase solubility studies.
• Formulation development using computational methods- QbD, BOE(Design expert).
• Statistical Analysis.
• Development of novel Drug Delivery systems-Liposomes, Neosomes , transferosomes.
• Bioavailability studies in animal models.
• Pharmacokinetic calculations using computational techniques.

PHARMACOGNOSTICAL RESERACH

• Hot continuous extraction technique by soxhlet apparatus for crude extracts using various solvent systems.
• TLC  method development for herbal substances, herbal Drugs , herbal formulations and ayurvedic formulations.
• Standardization of herbal materials by Physical and Chemical methods like ash value, extractive values, loss on drying and Phytochemical Tests.
• Analytical Evaluation of edible oils by acid value, saponification value ,ester value and iodine value.
• Laboratory based extraction of powdered crude drug with organic solvents.
• Phytochemical screening and TLC profile of crude drugs,extracts or fractionated extracts.
• Powder Microscopy of crude drugs: image documentation.
• Loss on drying,Ash values and Extractive values
• Developing solvent system for HPTLC profiling
• Standardisation of Indigenous formulations.